MIC 4124 Study Guide - Midterm Guide: Phosphoprotein, Virulence Factor, Genetic Screen

• School: University of Ottawa
• Department: Microbiology and Immunology
• Course: MIC 4124
• Professor: Thien Fah Mah

Document Summary

A microbe that is capable of causing damage to its host and spends at least part of its lifecycle within a host cell or host cell vacuole. The ability of the pathogen to establish a niche within its host. E. g. : through biofilms or living inside host cells (intracellular pathogens) E. g. : low ph, shear stress due to the circulatory system, complement system, antibodies, macrophages, t-cells, etc. Bacteria can hide out and replicate inside the cell cytoplasm or inside vacuoles (phagosomes) within cells. Listeria monocytogenes* listeriosis: mycobacterium tuberculosis* tuberculosis. By professional phagocytes like neutrophils, macrophages, and dendritic cells. By cells that are not normally phagocytic (e. g. : endothelial and epithelial cells) A receptor-mediated, actin-driven process whereby foreign objects larger than 0. 5 um are internalized and degraded. Initial engulfment, then vesicle formation into a phagolysosome. As it progresses, different vesicles fuse to deliver different proteins. Salmonella can induce its own uptake into a normally non- phagocytic cell.