[MIC4124] - Final Exam Guide - Ultimate 49 pages long Study Guide!
30 Mar 2017
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Prokaryotic cell structure and function: cocci arranged in clusters or chains, diplococci with one plane of division, tetrads with 2 planes of division, sarcinae have 3 plans of division to make cubical packet of 8 cells. Integral proteins compose 70-80% of total membrane protein: flagellum for cellular movement. Inactivation of genes associated with virulence trait should decrease pathogenicity: replacement of mutated gene with the normal wild type gene should fully restore pathogenicity. Infectious diseases are a leading cause of death world wide: tb causes a chronic infection in the lungs, spread by airborne droplets, multidrug resistance, many evolutionary events have been linked to infectious disease, bubonic plague. Interaction between pathogenic activity and host defenses determines final outcome: replication, growth and reproduction, facultative intracellular pathogens or obligate intracellular pathogens, damage to host. Indirect damage produced by host immune defenses in response to infection: direct damage by mechanical disruption of cell function, induction of apoptosis, or toxins, exotoxins are secreted or released.
