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Midterm

PHA3112 Midterm: drug list quiz study guide

10 Pages
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Department
Pharmacology
Course Code
PHA3112
Professor
Frank Feiner

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Amantadine Duodopa, sinemet
Benzotropine Mirapex
Entacapone eldepryl
Levodopa and carbidopa Cogentin
Pramipexole comtan
Selegiline Symmetrel
Memantine
Rivastigmine
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Parkinsons
1. We convert to DA in the brain. One of us blocks the destruction of the other, and we are a first
line drug. I’m used as a dopamine replacement.
2. I directly activate DA receptors, and I’m used as a first line drug supplement or to supplement
levodopa. I’m a dopamine agonist.
3. I inhibit the breakdown of levodopa by COMT, I’m safer than levodopa
4. I inhibit the breakdown of dopamine by MAO-8, I’m used for newly diagnosed patients and for
“off” times during levodopa therapy.
5. I promote the release of DA from remaining DA neurons: I may also block DA reuptake, AND
may help reduce levodopa induced dyskinesia.
6. I block muscarinic ACh receptors in the striatum, and I block PNS ACh receptors. I have many
side effects! Some include dry mouth, constipation, urinary retention, tachycardia, photophobia
and blurred vision. I have a safety alert to NOT use in elderly.
7. I directly activate DA receptors
8. Converts to DA in brain
9. Blocks muscarinic ACh receptors in striatum and PNS
10. Inhibit the breakdown of levodopa by COMT
11. Inhibits breakdown of DA by MAO-8
12. Promotes release of DA from remaining DA neurons.
13. What do the trials for pimavanserin indicate?
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Alzheimer’s
1. I help treat the symptoms of AD, and I block neuronal receptors for NMDA
2. I am a cholinesterase inhibitor, and I produce only a modest improvement in cognitive function.
Multiple Sclerosis
1. I decrease the autoimmune destruction of myelin, however I’m the only FDA approved
immunosuppressant for treating MS
2. I suppress immune cells
3. I reduce lymphocytes, which reduces the inflammation that underlies neuronal injury
4. I suppress t-helper cell activity
5. I inhibit the migration of proinflammatory leukocytes across the BBB, preventing them form
reaching neurons of the CNS
6. I’m effective, but can cause significant side effects
7. I suppress the production of B/T lymphocytes, and macrophages.
8. I cause a harmless, blue/green tint to urine, sclera and skin
Seizures and epilepsy
1. What are the 3 drugs that reversibly bind to Na channels on neuron membranes and then
decrease Na entry?
2. What drug blocks the actions of glutamate at NMDA and AMPA receptors, which then suppress
neuronal excitement? (potentiation of GABA)
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Description
Amantadine Duodopa, sinemet Benzotropine Mirapex Entacapone eldepryl Levodopa and carbidopa Cogentin Pramipexole comtan Selegiline Symmetrel Memantine Rivastigmine Parkinsons 1. We convert to DA in the brain. One of us blocks the destruction of the other, and we are a first line drug. I’m used as a dopamine replacement. 2. I directly activate DA receptors, and I’m used as a first line drug supplement or to supplement levodopa. I’m a dopamine agonist. 3. I inhibit the breakdown of levodopa by COMT, I’m safer than levodopa 4. I inhibit the breakdown of dopamine by MAO-8, I’m used for newly diagnosed patients and for “off” times during levodopa therapy. 5. I promote the release of DA from remaining DA neurons: I may also block DA reuptake, AND may help reduce levodopa induced dyskinesia. 6. I block muscarinic ACh receptors in the striatum, and I block PNS ACh receptors. I have many side effects! Some include dry mouth, constipation, urinary retention, tachycardia, photophobia and blurred vision. I have a safety alert to NOT use in elderly. 7. I directly activate DA receptors 8. Converts to DA in brain 9. Blocks muscarinic ACh receptors in striatum and PNS 10. Inhibit the breakdown of levodopa by COMT 11. Inhibits breakdown of DA by MAO-8 12. Promotes release of DA from remaining DA neurons. 13. What do the trials for pimavanserin indicate? Alzheimer’s 1. I help treat the symptoms of AD, and I block neuronal receptors for NMDA 2. I am a cholinesterase inhibitor, and I produce only a modest improvement in cognitive function. Multiple Sclerosis 1. I decrease the autoimmune destruction of myelin, however I’m the only FDA approved immunosuppressant for treating MS 2. I suppress immune cells 3. I reduce lymphocytes, which reduces the inflammation that underlies neuronal injury 4. I suppress t-helper cell activity 5. I inhibit the migration of proinflammatory leukocytes across the BBB, preventing them form reaching neurons of the CNS 6. I’m effective, but can cause significant side effects 7. I suppress the production of B/T lymphocytes, and macrophages. 8. I cause a harmless, blue/green tint to urine, sclera and skin Seizures and epilepsy 1. What are the 3 drugs that reversibly bind to Na channels on neuron membranes and then decrease Na entry? 2. What drug blocks the actions of glutamate at NMDA and AMPA receptors, which then suppress neuronal excitement? (potentiation of GABA) 3. What alternative methods can be used to treat epilepsy? Local anesthetics 1. What are the two groups and what are their prototypes? 2. Which prototype is not available in Canada? 3. What is often co-administered with local anesthetics? 4. What a
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