PHA3112- Final Exam Guide - Comprehensive Notes for the exam ( 24 pages long!)

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Frank Feiner

Document Summary

Pharmacodynamics: effects of drugs and mechanism of action (dose-response relationship: deter(cid:373)i(cid:374)es (cid:1005)(cid:895) (cid:373)i(cid:374) (cid:454) a(cid:373)ou(cid:374)t, (cid:1006)(cid:895) (cid:373)a(cid:454) respo(cid:374)se, (cid:1007)(cid:895) ho(cid:449) (cid:373)u(cid:272)h to dose for desired respo(cid:374)se, *efficacy: largest effect drug can produce (ex. More pain relief: potency: amount of drug needed to produce a given effect (ex. Slow, variable due to epithelial lining of gi tract + capillary wall. Rapid onset, precise control, large fluids & irritants ok. Irreversible, $, difficult, potential injury, fluid overload/infection risk, embolism. Bioavailability (f): fraction of unchanged rx that reaches systemic circulation: f = auc po oc dose absorbed / auc iv oc dose administered. Cyp: enzyme inducer: rates of metabolism of a substrate drug, enzyme inhibitor: rates of metabolism of a substrate drug. Time course of drug responses: minimum effective concentration: plasma drug level below which therapeutic effects do not occur, half-life: drugs with a short half-life must be admined more frequently, rx eliminated in 5 half-lives.