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Final

PHA3112 Final: Respiratory and Gastrointestinal Disorders
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Department
Pharmacology
Course
PHA3112
Professor
Frank Feiner
Semester
Winter

Description
Respiratory Gastrointestinal Disorders Chapter 76: Asthma COPD Asthma Chronic widespread disorder of children adults o 111 children, 112 adults: 2.6 million ill (Canada) 15 increase since ~ 2000 o 350 deathsyr Signs symptoms: o Breathlessness o Chest tightness pressure pain o Wheezing o Cough o Dyspnea (difficulty breathing) Underlying cause: Immune attack on resulting inflammation of airways Drug therapy highly effective o Most patients lead full lives w no limitation COPD Chronic widespread disorder of adults who smoke cigarettes o 2.4 million affected (Canada) Third leading cause of death Signs symptoms: o Chronic bronchitis Cough excessive sputum Wheezing Dyspnea Poor exercise tolerance Pathophysiology: airflow restrictions inflammation Chronic, progressive, largely irreversible Drug therapy benefits minimal Doesnt slow progression, reduce hospitalization or prolong life Mostly preventablestop cigarette smoking Asthma Pathophysiology Allergen binds via igE to mast cell activates it Inflammatory mediators (histamine, leukotrienes, prostaglandins, interleukins) released
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