PHS 4300 Study Guide - Midterm Guide: Renin, Bariatric Surgery, Phosphorylation

• School: University of Ottawa
• Department: Physiology
• Course: PHS 4300
• Professor: Frank Feiner

Document Summary

Gfr is the volume of fluid filtered from the glomerular capillaries into bowman"s capsule per unit time. Clinically gfr is measured to determine renal function: rate at which plasma moves through glomurular capillaries, 25% of cardiac output with 90% to cortex and 1-2% to medulla, 99% of volume is absorbed and 1% excreted. Driving force of gfr is glomerular capillary hydrostatic pressure. Gfr = kf (pgc (pt + copgc)) Kf = ultrafiltration coefficient includes capillary sa and fluid permeability. Ufp = net filtration pressure (ultra: (pgc (pt + copgc)) Measured using a substance that: must be freely filtered, must not be reabsorbed or secreted, must not be synthesizd or catabolised by the kidney, must not alter gfr. Creatinine clinical standard: creatinine is excreted mainly by filtration, creatinine is produced by skeletal muscle at a constant rate from creatine- phosphate. Amt excreted = amt filtered amt reabsorbed + amt secreted.