BIO202H5 Study Guide - Midterm Guide: Subventricular Zone, Neurogenesis, Bromodeoxyuridine
Document Summary
Neurogenesis is substantially reduced in older aged individuals despite the fact that the development of new neurons continues during adulthood in the subventricular zone of the hippocampus. Although many of the new cells survive and become mature, most of them degenerate by 4-5 weeks after cell division. The survival and proliferation of newborn cells are regulated by behavioral and environmental factors. Increased survival of newborn cells depends on the enriched environment and hippocampal-dependent learning. Little is known however about the intracellular signaling pathways that control the survival of newborn neurons in the adult hippocampus. camp second messenger cascade and the camp response element-binding protein (creb) are closely associated with this process. Our research will explore the role of the camp-creb pathway on the survival of newborn cells. First, we will show the relationship between phosphorylated creb (pcreb) and maturing newborn cells.
