BIO206H5 Study Guide - Final Guide: Guanosine, Purine, Deoxyribonuclease
Document Summary
Mrna: no need for further processing. Is either monocistronic or polycistronic: carries info for one/many genes. Rna polymerase: core + sigma ( ) Sigma is the variable unit, in that they"re what recognizes the different promoter regions: core contains 5 subunits: 2 recognizes upstream element at (-40 to -70) Performs polymerase activity deals with initiation & elongation. Stabilizes polymerase & acts as a molecular chaperone (maintain tertiary structure) for the rna poly. Recognizes (-10 to -35) region, binds there, & recruits the core complex. More complex organization condensed chromatin w/ histone proteins. Hetereogeneous nuclear mrna : this is processed to become mature mrna. Rna polymerase -- i, ii, & iii: rna pi: Located in chromatin & nuclear matrix: rna piii. Synthesizes smaller rnas (trna, 5s rrna, u6 snrna) Mediator protein which interacts with distal enhancer/repressor sequences. Chromatin remodelling complex assists the movement of the complex, opens & removes chromatin-making molecules would around dna ; also rebinds.
