BIO207H5 Study Guide - Final Guide: Genetic Linkage, Sickle-Cell Disease, Genotype Frequency

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1 Apr 2016
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Broad learning goals for the 207 final exam april 2013. **predict the probability of individuals having a genotype based on family history. **describe the molecular basis of different types of inheritance patterns. **identify the inheritance of sex-linked disorders on pedigrees. *describe the impact of random x-chromosome inactivation on phenotype. 14. explain how gene expression can be affected by nongenetic factors. 15. explain how gene expression can be affected by factors related to sex. 16. explain how gene expression can be affected by interactions with other genes. 17. use phenotype and genotype ratios to identify the mechanism of inheritance. *describe differences between complete and incomplete genetic linkage. 22. find the relative order of genes by three-point mapping. *describe the molecular basis of sickle cell disease. *describe how sickle cell disease evolved by natural selection. 35. describe the impact on protein structure depending on the type of mutation. 39. describe dna damage signaling systems. (e. g. , role of p53) 41. describe how nondisjunction leads to changes in chromosome number.