[BIO380H5] - Final Exam Guide - Everything you need to know! (59 pages long)
Document Summary
Lecture 2 - structural and functional maturation of egg and sperm (pg 7-14) Phase 1: the origin and migration of germ cells. Specification starts in the hindgut and migrate (germ cell migration - even happens in flies) to the developing gonad through the dorsal mesentery. Undergoing mitosis during migration (multitasking to expand the population) Teratomas - when pcgs get lost during migration. The embryo is very small at this time so it gets complicated - cancer, spontaneous abortions etc. These germ cells are the original stem cells - super mitotic and can become anything. Phase 1: increase the number of germ cells by mitosis. As soon as they are in the gonads, the primitive germ cells are called oogonia and spermatogonia. Rapid mitotic divisions to produce diploid progeny (genetically identical) - Oogonia - during 2-5 month of pregnancym few thousand to 7 million which representt he max number of germ cells ever found in the ovary (decrease during lifetime)
