BIO200 Lecture 2

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Department
Biology
Course
BIO200H5
Professor
Mc Intyre Burnham
Semester
Fall

Description
Lecture 2 September-12-13 5:05 PM Time you test in between the drugs 30 min is often a good time (except Vitucilin no effect in 30 min) Test toxicity first -Testing a variety of doses -Slowly increase dose until you see effect or toxicity -Dose response - you increase dose and see response Less toxicity is a better drug Chemotherapy are toxins (very poor therapeutic) R R R D D D We test in intervals because we get dose response that is very usual 2. Inverted U - comes out to a solution if you put a lot 3. Drug will increase locomotion Happens when dealing with neurotransmitter Lowest doses - turn off synapse Highest doses - turn on synapse No Rmax Drug is binding to a protein binding site- after the point Ex. Anti-acid - no protein binding site where it occupies all site, stops increasing response Lectures Page 1 Drug is binding to a protein binding site- after the point Ex. Anti-acid - no protein binding site where it occupies all site, stops increasing response Take 10 rats - give different doses each time Dose increase = blood level increase Graph level off = Rmax = all animals are having seizure Rmax ED50 B Drug B is less potent because you have to go higher doses to get effect Double DOSE = log DOSE is increasing Semi-log plot - you get the wh
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