BIO200 Lecture 3

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University of Toronto Mississauga
Mc Intyre Burnham

Lecture 3 September-17-13 12:39 PM Outside of cell Lectures Page 1 Ability of molecules to dissolve from one phase to another O attracts better than H can be added to the non-binding parts of the drug molecule. This will increase the solubility without disturbing the drug effect Lectures Page 2 In water molecules, the drug forms lattices. NO attraction b/w drug molecule and the lipid molecule. They are forced into lipid membranes by moving out water lattices Very high fat soluble Carcinogenic Easily enter the body Lectures Page 3 P - Partition coefficient O/W - Oil/water Non polar - mostly lipid phase -usually RBC We don’t find it easily in tables Lectures Page 4 <1 concentrated in water >1 concentrated in fat =1 equal concentration in fat and water Lectures Page 5 Branches tend to make the molecule more water soluble Hydroxyl - more water soluble Concentration in water is higher than it is in fat - Ionized is charged Lectures Page 6 Charged = Weak acid or weak base Both basic and acidic group parts - one will dominate over the other. ex. Morphine (considered base) Lectures Page 7 pKa - half ionic and half non-ionic form of an ionic compound pH - experimental number At pKa, drug will be half charged and half uncharged As we move to more acidic medium, molecule will become more and more uncharged
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