BIO200 Lecture 5

14 Pages
Unlock Document

University of Toronto Mississauga
Mc Intyre Burnham

Lecture 5 September-24-13 5:15 PM Low partition molecules have trouble moving through plasma membrane Body is >60% water - the cells are sealed tightly together, drug molecules have to pass through the cell to get to other cells - Also spot junctions - loosely aggregated, many spaces in between the cells Lectures Page 1 Plasma membranes are blood barriers (but we can neglect this for now) Capillary bed collect drugs and enzymes before proceeding to other organs P-Glycoprotein - an added barrier Lectures Page 2 We have many molecules that we don't want in the body Allow small drugs to pass through and blocks the big ones Pores are on the tissue which allow the drugs to pass through Lectures Page 3 There are no spaces (molecules have to get through the cell) - Blood brain barrier Peptides (not soluble, low partition) Water soluble, but have to go through brain fluid Chemical trigger zone (CTZ) Part of hypothalamus (monitor - One of the work centers blood, sugar content) so it can't be a barrier - Makes you think that you are poisoned and makes you throw up Major seizure will make the barrier dysfunctional A lot of peptide hormones are also used in the brain but for different purpose. Thus, they are kept away from brain to keep the signals separate Lectures Page 4 Lining of ventricle - ependyma (barrier b/w blood and CSF)
More Less

Related notes for BIO200H5

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.