BIOC21H3 Study Guide - Final Guide: Tumor Necrosis Factor Alpha, Mononuclear Phagocyte System, Collagenase

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Can tell them apart via 3 things: see indentations in nucleus, nucleus darker staining, and will definitely know its a macrophage if u see it engluphing something. Interleukins signal for a specific type of wbc to come in response to a specific pathogen. Interleukins can target b lymphocytes, causing them to convert into a plasma cell, and produce a specific antibody in response to that pathogen. Contains intensely staining, metachromatic granules (stain with toluidine blue. ) goes from blue to red. heparin inhibits clot formation, recall that macrophages can release tnf alpha increasing permeability though endothelium, don t want to counteract that. histamine is a bronchoconstrictor and a vasodilator. Why have vasodilation, want to slow the flow of things, not so fast/high pressue. Causes endothelial cells to pull away from each other, making open pores. Get fluid release, and as a result, localized swelling (essentially diluting the pathogen)

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