BIOC32H3 : Skeletal muscle 3
Document Summary
If a muscle is stimulated repetitively enough or at a fast enough frequency, it will ultimately fatigue and no longer be able to generate tension and contract. Muscle fatigue can occur as a result of processes in the muscle or processes at the neuromuscular junction (synapse). Within the muscle, fatigue can occur because of: glycogen depletion (glycogen being the primary source for atp production), a reduction in intracellular ph (accompanied by lactic acid buildup). The reduction in ph reduces the efficiency of enzymes and other proteins which have a ph optima at which they function best: a calcium imbalance. At the neuromuscular junction, fatigue can occur because of the depletion of the neurotransmitter, acetylcholine. The objective of the synaptic fatigue laboratory exercises is to observe and distinguish muscle fatigue due to fatigue within the muscle or fatigue within the neuromuscular junction (nmj). You first stimulate the right sciatic nerve and watch the right gastrocnemius muscle contract.