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Department
Biological Sciences
Course Code
BIOC34H3
Professor
Stephen Reid

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Lecture 18 Study Notes
Slide 2
We have 3 sources of Calcium
oBone
Deposition (calcification) of Calcium into bones reduces plasma
Calcium levels
Resorption (break down) of bone increases plasma calcium levels
oGut
Plasma absorbs calcium from the gut
So the gut does not store calcium
oKidneys
Kidneys could filter calcium from the blood (filtration)
Or plasma could reabsorb calcium from the kidneys (reabsorption)
Regulation of Calcium in the body is controlled by hormones
oParathyroid hormone and Calcitrol hormone
They both raise Calcium plasma levels
oCalcitonin
Reduces Calcium plasma levels
Hypocalcaemia: low blood Calcium
Hypercalcaemia: high blood calcium
Slide 3 - 6
Calcitonin
oReduces calcium plasma levels
oProduced by the thyroid gland
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oProduced in response to high calcium plasma levels, in order to reduce the
high level
oActs on kidneys and bone
oHigh Calcium levels thyroid gland calcitonin deposition/calcification
into bone and promotes filtration into kidney reduces calcium plasma
levels
Parathyroid hormone
oIncreases calcium plasma levels
oProduced by parathyroid gland
oProduced in response to low calcium levels, in order to increase calcium levels
oActs on kidneys and bone
oLow calcium plasma level parathyroid gland parathyroid hormone 
resorption of bone and reabsorption into bloodstream from kidneys
increased calcium plasma level
So basically:
oIf plasma [Ca++] Calcitonin Release Lowers plasma [Ca ++]
oIf plasma [Ca++] PTH Release Raises plasma [Ca  ++]
Slide 7
Calcitrol
oIncreases Calcium plasma levels
oNot produced in a gland
But is instead derived from cholesterol
oActs on guts and kidneys
oCholesterol 7-Dehydrocholesterol vitamin D3 25-Hydroxyvitamin D3
Calcitrol promotes absorption from gut and reabsorption from kidney
into blood increased Ca level
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Description
Lecture 18 Study Notes Slide 2 We have 3 sources of Calcium o Bone Deposition (calcification) of Calcium into bones reduces plasma Calcium levels Resorption (break down) of bone increases plasma calcium levels o Gut Plasma absorbs calcium from the gut So the gut does not store calcium o Kidneys Kidneys could filter calcium from the bloodiltration) Or plasma could reabsorb calcium from the kidneys(reabsorption) Regulation of Calcium in the body is controlled by hormones o Parathyroid hormone and Calcitrol hormone They both raise Calcium plasma levels o Calcitonin Reduces Calcium plasma levels Hypocalcaemia: low blood Calcium Hypercalcaemia: high blood calcium Slide 3 - 6 Calcitonin o Reduces calcium plasma levels o Produced by the thyroid gland www.notesolution.com
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