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BIOC34H3 Study Guide - Quiz Guide: Metabolic Acidosis, Proximal Tubule, Ph


Department
Biological Sciences
Course Code
BIOC34H3
Professor
Stephen Reid
Study Guide
Quiz

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BIOC34; Fifth Assignment (2013): PhysioEx Lab 10 (Acid-Base Balance)
Farzook Fayyaz
998441397
Activity 1: Hyperventilation
Provide the data recorded from the experiments in this section (i.e., chart 1; normal breathing,
hyperventilation and normal/hypervention). (2 marks)
Condition Min. PCO2 Max. PCO2 Min. pH Max. pH
Normal 40 40 7.40 7.40
Hyperventilation 19.7 40 7.39 7.69
Hyperventilation/Normal 35.3 40 7.38 7.47
Activity 2: Rebreathing
Provide the data recorded from the experiments in this section (i.e., chart 2). (2 marks)
Condition Min. PCO2 Max. PCO2 Min. pH Max. pH
Normal 40 40 7.39 7.39
Rebreathing 40 53.02 7.25 7.42
Activity 3: Renal Responses to Respiratory Acidosis and Alkalosis
Provide the data recorded from the experiments in this section (i.e., chart 3). (2 marks)
PCO2 Blood pH [H+] in urine [HCO3-] in urine
40 7.39 normal normal
30 7.61 decreased elevated
60 7.31 elevated Decreased
Activity 4:Respiratory Responses to Metabolic Acidosis and Alkalosis
Provide the data recorded from the experiments in this section (i.e., chart 4). (2 marks)
Metabolic
Rate (kcal/hr)
BPM
(breaths/min)
Blood pH PCO2 [H+] in blood [HCO3-] in
blood
50 15 7.40 40 40 24
60 17 7.34 45 47 20
80 21 7.26 55 63 14.50
40 13 7.44 37 38 26
20 9 7.51 31 32 30
Questions
1) Drugs such as SIDS or DIDS block the activity of chloride-bicarbonate exchangers. Illustrate, on a
pH-bicarbonate (Davenport) diagram, the effects (on acid-base balance) of adding SIDS or DIDS to
the proximal tubule epithelial cells in the kidneys. Explain your diagram. (4 marks).
Due to blockage in the chloride-bicarbonate exchanger of the proximal tubule, the bicarbonate
reabsorption from the kidneys into the blood is little to none. Consequently, blood bicarbonate levels
would decrease (resulting in a metabolic acidosis). The Davenport diagram below illustrates that the
position has shifted from normal blood values (point 1) to point 2 (along the pCO2 isobar with no pCO2
change). This shows the reduction in both the pH and in bicarbonate levels.
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