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Department
Biological Sciences
Course Code
BIOC34H3
Professor
Stephen Reid

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Lecture 5 Study Notes
There are 3 factors that regulate Stroke volume
1.Force of ventricular contraction: slide 7 - 8
This occurs through sympathetic innervation
oNE or NA act on the Beta cells of the heart, which activate Gs protein
that transform ATP into Camp. (Alpha cells as negative feedback)
oCamp then acts on PKA, which:
Opens Calcium channels , allowing for Ca increase
Acts together with increased Ca to cause Sarcoplasmic Reticulum to
release calcium, increasing intracellular calcium
oCardiac NerveNE Beta cells Gs Turn ATP into
CAMP PKA Open CA channels & PKA Increased
intracellular Ca Contraction
oIncreased Calcium in the intracellular leads to :
More calcium binding to troponin, resulting in more
crossbridge formation of thick myosin and thin actin
filaments
Increase in Calcium permeability in the sarcoplasmic
reticulum, resulting in release of more Calcium to
intracellular of cell (Calcium induced Ca release)
2.EDV
Remember EDV is when the ventricles have highest blood volume
Starling Curve: relationship b/n stroke volume and EDV.
oAs EDV increases
SV increases (more blood available to pump out in systole)
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Description
Lecture 5 Study Notes There are 3 factors that regulate Stroke volume 1. Force of ventricular contraction: slide 7 - 8 This occurs through sympathetic innervation o NE or NA act on the Beta cells of the heart, which activate Gs protein that transform ATP into Camp. (Alpha cells as negative feedback) o Camp then acts on PKA, which: Opens Calcium channels, allowing for Ca increase Acts together with increased Ca to cause Sarcoplasmic Reticulum to release calcium, increasing intracellular calcium o Cardiac NerveNE Beta cells Gs Turn ATP into CAMP PKA Open CA channels & PKA Increased intracellular Ca Contractio
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