BIOC34H3 Study Guide - Beta Cell

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4 May 2011
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There are 3 factors that regulate stroke volume: force of ventricular contraction: slide 7 - 8. this occurs through sympathetic innervation: ne or na act on the beta cells of the heart, which activate gs protein that transform atp into camp. (alpha cells as negative feedback, camp then acts on pka, which: acts together with increased ca to cause sarcoplasmic reticulum to release calcium, increasing intracellular calcium: cardiac nervene beta cells gs turn atp into. Camp pka open ca channels & pka increased intracellular ca contraction: increased calcium in the intracellular leads to : more calcium binding to troponin, resulting in more crossbridge formation of thick myosin and thin actin filaments. i ncrease in calcium permeability in the sarcoplasmic reticulum, resulting in release of more calcium to intracellular of cell (calcium induced ca release: edv. remember edv is when the ventricles have highest blood volume.

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