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BIOC34H3 (46)

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Department
Biological Sciences
Course Code
BIOC34H3
Professor
Stephen Reid

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Lecture 13 Study Notes
Slide 2
While resting, we only utilize ¼ of oxygen in circulation
oThe other 75% is on reserve i.e. for when we exercise or increase metabolic
demands
Slide 3 (look at graph)
Polycythaemia: overproduction of red blood cells
oGreater than normal amount of haemoglobin then.
Even though 100% saturation of Hb with O2 occurs, polycythaemia
means total oxygen level is higher than normal
Anaemia: reduction of red blood cells
oLess than normal amount of haemoglobin
Even though 100% saturation of Hb with O2 occurs, anaemia means
total oxygen level is lower than normal
Slide 4
Oxygen haemoglobin binding is modified by a variety of factors including
temperature, pH, PCO2, and 2,3-DPG
oTemperature and pH most important
oThese factors promote oxygen loading in the lungs and oxygen unloading in
the tissues
Remember loading was promoted in lungs due to high PO2 (100 torr),
and unloading promoted in tissues due to low PO2 (40 torr)
Slide 5
Factor 1: Temperature
oMetabolically active tissues have higher temperatures. So
Temperature
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p50
affinity for oxygen
Hence we have unloading in tissues(also due to lower PO2)
oTemperature is reduced in the lungs (i.e breathing in air cooler than body
temp). So
Temperature
p50
affinity for oxygen
This results in enhancing loading of oxygen (also due to higher
PO2)
Slide 6
Factor 2: pH
oMetabolically active tissues have lower pH . So
Ph
p50
affinity for oxygen
So unloading is also enhanced by decreased pH
Carbamino effect: CO2 is also capable of binding to haemoglobin
oOpposite
pH
p50
affinity for oxygen
Slide 7 and Slide 8
Factor 3: 2,3 DPG or 2,3-diphosphoglycerate
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Description
Lecture 13 Study Notes Slide 2 While resting, we only utilie of oxygen in circulation o The other 75% is on reserve i.e. for when we exercise or increase metabolic demands Slide 3 (look at graph) Polycythaemia: overproduction of red blood cells o Greater than normal amount of haemoglobin then. Even though 100% saturation of Hb with O2 occurs, polycythaemia means total oxygen level is higher than normal Anaemia: reduction of red blood cells o Less than normal amount of haemoglobin Even though 100% saturation of Hb with O2 occurs, anaemia means total oxygen level is lower than normal Slide 4 Oxygen haemoglobin binding is modified by a variety of factors including temperature, pH, PCO2, and 2,3-DPG o Temperature and pH most important o These factors promote oxygen loading in the lungs and oxygen unloading in the tissues Remember loading was promoted in lungs due to high PO2 (100 torr), and unloading promoted in tissues due to low PO2 (40 torr) Slide 5 Factor 1: Temperature o Metabolically active tissuese higher temperatures. So Temperature www.notesolution.com
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