BIOD27H3 Final: Final Exam Study Guide

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5 Dec 2010

Document Summary

Endocrine glands/cells = secrete chemical messengers directly into blood. Effect over time sec, min, hour, day, week, month. Growth and development, metabolism, regulates temp, ph, water balance, hunger, reproduction. Hormone effect depends on tissue type and development stage. Enzymes degrade it into inactive metabolites liver, kidneys. Half life = time needed to decrease hormone concentration in blood by half. E. g. melatonin, thyroid hormone: peptide hormone. Most common = made all over body. Lipophobic b/c binding to membrane receptor. Fast acting life = minutes. E. g. pituitary hormones, pancreas hormones insulin, glucagen. Have signal sequence that directs it to rer. Lipohilic receptor w/in target cell [cytoplasm/nucleus] Bind dna to activate/turn off protein synthesis. Not soluble in plasma/body fluids = hydrophobic need carrier protein for circulation [sometimes specific = corticosteroid binding protein or are general plasma proteins = albumin] Aldosterone = mineralocorticoid controls water/sodium retention in kidneys. Male gonads secrete adrogens = testosterone and androsrenedione.

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