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BIOD60H3 Study Guide - Peptide, Oligosaccharide, Cytosol

Biological Sciences
Course Code
Shelley A.Brunt

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FSG Session #3: BIOB10Y3: Cell and Molecular Aspects of Genetic Processes
Section # 1: Terms to know
_________ _________: Special series of aminoacids located at the ___-terminal portion
of newly forming proteins that triggers the attachment of the protein-forming ribosome to
an __ membrane and the movement of the nascent polypeptide into the cisternal space of
the ER.
Section # 2: Short Answers
1) What is happening at the following steps (1, 2, 3, 4)?
2) What are the characteristics of signal sequences that target proteins to the ER?
3) A tissue that secretes a number of proteins is exposed in culture to radiolabeled amino acids for
a very short time and then fixed immediately and prepared for autoradiography. What is seen
after the autoradiograms are prepared?
4) What are some properties/functions of SER and how are proteins targeted here?
5) Enzymes that add sugars on proteins are known as? In N-linked glycosylation sugar chains are
added to asparagine that is located in which motif? Describe the steps of the N-linked
glycosylation. What is the purpose for adding these sugars onto the proteins?
6) a)You are on your way to class this Thursday and as you are walking towards the lecture hall
an elementary school student stopped you and asked you to explain to them the quality control
pathway of protein in the ER. You don’t want to confuse the child so your explanation should be
b) The same elementary school student was so impressed with you above explanation that he
wanted you to tell him more about what happens when proteins are terminally misfolded. Also be
sure to tell him what happens if large amounts of unfolded proteins accumulate in the ER.
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