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BIOC21H3 Study Guide - Final Guide: Tumor Necrosis Factor Alpha, Mononuclear Phagocyte System, Collagenase

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School
UTSC
Department
Biological Sciences
Course
BIOC21H3
Professor
Stefan Rusyniak

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Document Summary

Can tell them apart via 3 things: see indentations in nucleus, nucleus darker staining, and will definitely know its a macrophage if u see it engluphing something. Interleukins signal for a specific type of wbc to come in response to a specific pathogen. Interleukins can target b lymphocytes, causing them to convert into a plasma cell, and produce a specific antibody in response to that pathogen. Contains intensely staining, metachromatic granules (stain with toluidine blue. ) goes from blue to red. heparin inhibits clot formation, recall that macrophages can release tnf alpha increasing permeability though endothelium, don t want to counteract that. histamine is a bronchoconstrictor and a vasodilator. Why have vasodilation, want to slow the flow of things, not so fast/high pressue. Causes endothelial cells to pull away from each other, making open pores. Get fluid release, and as a result, localized swelling (essentially diluting the pathogen)

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Related Questions

Neutrophils and macrophages are both phagocytic cells. How do these cells recognize foreign cells. (include the receptors and tell me which ones are common to neutrophils and which are on macrophages).

Both macrophages and neutrophils are described as agranular leukocytes that are phagocytic.

There are basically three different types of pathogen invasion Γ’Β€ΒœstrategiesҀ Ҁ“ extracellular, intracellular in non-phagocytes like epithelial cells, and intracellular in circulating phagocytes like Macrophages. That is, some bacteria try to remain outside of the host cells, while other bacteria and viruses get inside different types of host cells and survive there.

A. For EXTRACELLULAR pathogens, describe advantages and disadvantages of this strategy. How does our immune system detect and eliminate such pathogens? Explain two virulence factors that this sort of pathogen can use to survive in its chosen environment.

B. For pathogens that are INTRACELLULAR IN MACROPHAGES, explain how they gain access to macrophages. Describe advantages and disadvantages of this strategy. How does our immune system detect and eliminate such pathogens? Explain two virulence factors that this sort of pathogen can use to survive in its chosen environment.

C. For pathogens that are INTRACELLULAR IN EPITHELIAL CELLS, explain how they enter the epithelial cells. Describe advantages and disadvantages of this strategy. How does our immune system detect and eliminate such pathogens? Explain two virulence factors that this sort of pathogen can use to survive in its chosen environment.