8 Pages

Biological Sciences
Course Code
Stefan Rusyniak

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LECTURE 9 LYMPHATIC TISSUES ANTIGEN-PRESENTING DIFFUSE LYMPHATIC LYMPH NODULES FOLLICULAR CELLS (APC) TISSUE (DLT) DENDRTIC CELLS - Phagocytic - Disorganized tissue usually - Localized clusters of - Collect Antigen- - Group of cells with MHC II found underneath epithelium lymphocytes, etc. Antibody complexes on complexes on their surfaces to in contact with the outside Well defined but not the cell surface allow for lymphocyte stimulation world (e.g., respiratory encapsulated This makes them - Phagocytosis, degradation and system, urinary system) Often associated with DLT available to presentation - Accumulations of - Found in: adjacent Antigen presentation is done leukocytes under epithelia Tonsils (Pharyngeal, Palatine, lymphocytes by a specialized cell surface Includes: Lymphocytes, Lingual) - Not considered an APC component MHC II Eosinophils, Plasma Ileum of the small intestine but has similar functions stimulate T- or B-lymphocyte Cells (Peyers Patches) found in No MHC II activation - Located at entry points the exact same spot always complex at the MHC II complexes only used into the body surface - Named based on location Appendix to present what the cell has - Have a boundary No phagocytosis of engulfed outside of itself MALT Mucosa - Sit on a reticular tissue network Ab-Ag complex once cell recognizes it, the cell Associated Lymphatic - Divide into 1 and 2 nodules: occurs will proliferate and produce Tissue Found in the 1) Primary Nodules mostly - Found at the germinal 1000s of lymphocytes that can Mucosal layer of composed of small centres recognize the antigen gastrointestinal, lymphocytes - Have long branching - Includes most members of the respiratory and Display fairly uniform processes with Mononuclear Phagocyte System genitourinary tracts staining lymphocytes in between (MPS) Often subdivided into: Inactivated, has not come them large Macrophages 1) GALT Gut across a pathogen - FDC spread out their Kupfer Cells: specialized Associated 2) Secondary Nodules projections to collect macrophages within the liver Lymphatic Tissue material passing through 2) BALT Mantle (outer rim) of from afferent lymph vessel Langerhans Cells: found small lymphocytes within skin (embedded in Bronchus Have a light-staining Sticky; grabs epidermis); migrate out of skin Associated germinal center passing protein and into lymph vessel and travel to Lymphatic Tissue (proliferated lymphocytes; has them flow nearest lymph node to activate - Usually lined by stratified where lymphocytes have through/along other cells for immune epithelia (tougher to get been activated) due to lots surface of cell response through than simple epithelia) of cytoplasm from large interacts with B- B-lymphocytes - Embedded in the loose CT lymphocytes lymphocyte on FDC - Includes Epithelioreticular under epithelia (Tunica surface Cells (REC) (thymus) mucosa) Not part of MPSLYMPH NODE THYMUS SPLEEN Type Of 2 Lymphatic Organ 1 Lymphatic Organ 2 Lymphatic Organ (largest) Organ Structure - Encapsulated (incomplete capsule) - Bilobed, somewhat heart-shaped - Encapsulated (dense irregular CT) thick, dense irregular CT - Transient structure continuous capsule (smooth muscle - Capsule = type I collagen, fibroblasts, Fully functional at birth sometimes seen within capsule because of etc. Atrophies (decreases in size) and blood vessel going through it) - Kidney bean-shaped replaced by adipose tissue starting at - Capsule invaginates to form trabeculae - Capsule invaginates into the interior of puberty (involution) also occurs in Contain blood vessels the organ to form trabeculae gives bone marrow (from red to yellow) Trabeculae may appear to have porous structure - Encapsulated (dense irregular CT) muscle because of blood vessels - Composed of a reticular tissue network continuous capsule due to filtration occurring- Highly vascularized produced by reticular cells (specialized - Capsule invaginates to form - No afferent lymphatic vessels fibroblasts) septa/trabeculae - Not divided into cortex and medulla - Efferent lymphatic vessels, arteries and
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