Assignment 5.doc

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School
University of Toronto Scarborough
Department
Biological Sciences
Course
BIOC34H3
Professor
Stephen Reid
Semester
Fall

Description
1 BIOC34; Fifth Assignment (2013): PhysioEx Lab 10 (Acid-Base Balance) Farzook Fayyaz 998441397 Activity 1: Hyperventilation Provide the data recorded from the experiments in this section (i.e., chart 1; normal breathing, hyperventilation and normal/hypervention). (2 marks) Condition Min. PCO2 Max. P CO2 Min. pH Max. pH Normal 40 40 7.40 7.40 Hyperventilation 19.7 40 7.39 7.69 Hyperventilation/Normal 35.3 40 7.38 7.47 Activity 2: Rebreathing Provide the data recorded from the experiments in this section (i.e., chart 2). (2 marks) Condition Min. P Max. P Min. pH Max. pH CO2 CO2 Normal 40 40 7.39 7.39 Rebreathing 40 53.02 7.25 7.42 Activity 3: Renal Responses to Respiratory Acidosis and Alkalosis Provide the data recorded from the experiments +n this section (i.e.- chart 3). (2 marks) PCO2 Blood pH [H ] in urine [HCO ]3in urine 40 7.39 normal normal 30 7.61 decreased elevated 60 7.31 elevated Decreased Activity 4:Respiratory Responses to Metabolic Acidosis and Alkalosis Provide the data recorded from the experiments in this section (i.e., chart 4). (2 marks) Metabolic BPM Blood pH P [H ] in blood [HCO ] in CO2 3 Rate (kcal/hr) (breaths/min) blood 50 15 7.40 40 40 24 60 17 7.34 45 47 20 80 21 7.26 55 63 14.50 40 13 7.44 37 38 26 20 9 7.51 31 32 30 Questions 1) Drugs such as SIDS or DIDS block the activity of chloride-bicarbonate exchangers. Illustrate, on a pH-bicarbonate (Davenport) diagram, the effects (on acid-base balance) of adding SIDS or DIDS to the proximal tubule epithelial cells in the kidneys. Explain your diagram. (4 marks). Due to blockage in the chloride-bicarbonate exchanger of the proximal tubule, the bicarbonate reabsorption from the kidneys into the blood is little to none. Consequently, blood bicarbonate levels would decrease (resulting in a metabolic acidosis). The Davenport diagram below illustrates that the position has shifted from normal blood values (point 1) to point 2 (alonCO2hisobar with no pCO2 change). This shows the reduction in both the pH and in bicarbonate levels. 2 50 - 45 40 mmHg [HCO ] 3
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