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BIOD65H3 Study Guide - Final Guide: Proceedings Of The National Academy Of Sciences Of The United States Of America, Biochimica Et Biophysica Acta, Nature Medicine

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School
UTSC
Department
Biological Sciences
Course
BIOD65H3
Professor
Joanne Nash

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Document Summary

Amyloid, promotes app transport to synapses and protects against beta-amyloid-related. Annals of the new york acad of sciences. 1366: 211: all neurodegenerative diseases = neuronal loss & progressive brain atrophy . For example, in ad, a deficiency in cytochrome oxidase results in mitochondrial dysfunction which leads to the generation of ros and then cell death. Nd, it could be the presence of ros that results in mitochondrial dysfunction. Although there is energy impairment in hd also, which is thought to involve mito, the mechanism is unclear. 2011: wild-type sod1 can take on various conformations inducing similar pathological states in both familial and sporadic cases of als (bosco et al. , 2010: mechanism of mitochondrial dysfunction is apparently due a portion of misfolded mutant sod1 being bound to the cytoplasmic-facing domain of. Vdac1, found on the outer mitochondrial membrane of affected tissues (israelson et al.

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Related Questions

If a substance is a neurotransmitter, stimulation of thepresynaptic cell should have the same effect as

Select one:

a. direct application of the proposed substance to thepostsynaptic cell.

b. stimulation of the postsynaptic cell.

c. blocking receptors on the postsynaptic cell.

d. inactivating the substance.

Which of the following is NOT true regarding metabotropicreceptors?

Select one:

a. The receptor itself is an ion channel that opens upon ligandbinding

b. The receptor has one subunit with seven transmembranedomains

c. They are coupled to intracellular G proteins

d. When activated they can stimulate effector enzymes

The classical neurotransmitters do NOT include

Select one:

a. acetylcholine.

b. amino acids.

c. neuropeptides.

d. monoamines.

Please answer these questions and please explain in details.

1- If you increase the extracellular concentration of Na+ ions,what effect would this have on the various steps of an actionpotential?

2- If you increase the extracellular concentration of K+ ions,what effect would this have on the various steps of an actionpotential?

3- Which of the following changes (or effects ofdrugs/poison/venom) at the synapse would decrease/increase themagnitude of graded potentials generated on the on the postsynaptic cell?

From the following list, select all options that are correctwith respect to the synapse.

Question 5 options:

A)

the synapse is the site where the plasma membrane that coversthe axon terminal of one neuron makes direct contact with and fusesto the plasma membrane on the cell body or dendrite of anotherneuron
B)

the action potential travels through extracellular fluid in thesynapse to get from one neuron to the next
C)

presynaptic nerve terminals release chemical messengers into thesynapse in response to arrival of an action potential
D)

signaling molecules in the synapse can be broken down by enzymesthat are present on the post synaptic cell membrane
E)

signaling molecules in the synapse can bind to 're-uptake'receptors and be taken back into the presynaptic neuron forbreakdown or for repackaging/reuse
F)

signaling molecules can be taken into and degraded within thepostsynaptic cell
G)

signaling molecules in the synapse function as chemicalmessengers that regulate the opening of ligand-gated channels inthe plasma membranes of post synaptic cells