CHMB62H3 Study Guide - Final Guide: Nucleoplasm, Multicellular Organism, Initiator Element

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Lec 7 p. 577-583, 587, 592 (9pages text) Ch. 33 the structure of informational macromolecules: dna & rna. 33. 1 a nucleic acid consist of bases linked to a sugar-phosphate backbone. Dna & rna = linear polymers, carrier of genetic info. Polymer monomer - consists of 3 components: sugar, phosphate, base. Sequence of bases characterize a unique nucleic acid & represent a form of linear info. Dna & rna differ in the sugar component & one of the bases. Sugar units in rna r ribose rather than deoxyribose. Rna use u base (uracil) instead of t base (thymine) Backbone of nucleic acid: chain of sugar linked by phosphodieste(cid:396) (cid:271)(cid:396)idge (cid:894)(cid:1007)"-oh grp of sugar bonded to phospho(cid:396)yl g(cid:396)p (cid:271)o(cid:374)ded to 5"-oh) Ve charge in phosphodieter linkage repel nucleophilic speices (ex. Hydroide ion), capable of cleaving the linkage of backbone important for maintain integrity of info stored in nucleic acid.

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