CLAA05H3 Study Guide - Final Guide: Maple Syrup Urine Disease, Rhodamine, Conformational Change
9 Feb 2015
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Mitochondria: arose from phagocytosis of aerobic prokaryote. Can divide in the cell: mitochondrial fission : powerhouse of the cell . Functions: site of aerobic respiration, utilizing oxygen to extract energy from macromolecules (primarily glucose) and converting it to atp. Mitochondria: we use 2 x 1026 molecules of atp/day, many mitochondria in: muscle cells, liver cells, fat cells, plant cells & sperm. Imm is 75% protein: lipid ratio (lipid= cardiolipin) Imm very impermeable due to cardiolipin: therefore channels & pumps are required to move things across. Protein translocons are also involved in import of proteins into mitochondria mitochondria chloroplast. Mitochondria proteins are completely translated on free ribosomes in cytosol. What is the targeting sequence of mitochondrial proteins: mitochondrial presequence . Several (+)-charged amino acids: internal sequence & stop transfer sequence. Stop transfer sequence embeds protein in the imm. Preprotein moves through tim because of membrane potential differences across. Associates with mt-hsp 70 which also helps pull it through.
