CLAA05H3 Final: Lecture 4&5 Lysosomes and PM Sept21&Oct1_1 slide per page.pdf
9 Feb 2015
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Friday, sept. 27th human exploration of space : Space shuttle veteran and first canadian on board the. Friday, sept. 27th brave genius : evolutionary biologist and evo devo pioneer, sean carroll. Saturday, sept. 28th postcards from mars : mars rover imaging scientist, jim bell. In the cis golgi, mannose sugars on lysosomal enzymes get phosphorylated: Clathrin binds to m-6-p receptor on cytosolic face. 8. 29b secreted protein lysosomal enzyme (carries mannose 6-p) Contains ~50 different hydrolytic enzymes made in rer. Range in size from 25 nm- 1 m in diameter. Digest contents brought into the cell by endocytosis or phagocytosis. Lysosomes can fuse with plasma membrane in a few cells to digest ecm (exocytosis) eg. osteoclasts- bone cells which exocytose lysosomes to degrade bone eg. sperm- sperm head head contains specialized lysosome called the acrosome. During fertilization the lysosome fuses with pm on sperm to release enzymes and digest egg"s outer covering.
