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Cornell-style notes, lecture 4

3 Pages
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Department
Environmental Science
Course Code
EESA10H3
Professor
Jovan Stefanovic

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Human Health and the Environment Study Notes
Lecture 4
Key pointsNotes
Chemical Hazards1.Endocrine Disrupters
2.Chemical Body Burdens
Endocrine DisruptersDirect effects:
bind to hormone receptors
alter the appearance of some genes
changes the level of produced proteins
Indirect effects:
alters hormone production, transport,
metabolism
endocrine glands produce hormones that
regulate functions in bodychemicals
(endocrine disrupters) mimic and disrupt
functions
adults are more resistant and recover
easily, pregnant not so much.
DES synthetic estrogen used to prevent
spontaneous abortion
effects: daughters of mothers who took
DES have many health problems (i.e.
reproductive organ disfunction, abornormal
pregnancy, lower fertility)
Endocrine DisruptersHealth Implications:
feminization of males
alter time to puberty
thyroid dysfunction: hormones affect brain
development, central nervous system
fetus is vulnerable.
Neurobehavioural effects:
before and after birth
PCBS: impaired learning, distractibility,
poor IQ tests, brain development.
Chemical Body BurdensChemicals accumulate in body, which is a
burden.
Builds up in tissues and difficult to break-
down
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Description
Human Health and the Environment Study Notes Lecture 4 Key points Notes Chemical Hazards 1. Endocrine Disrupters 2. Chemical Body Burdens Endocrine Disrupters Direct effects: bind to hormone receptors alter the appearance of some genes changes the level of produced proteins Indirect effects: alters hormone production, transport, metabolism endocrine glands produce hormones that regulate functions in bodychemicals (endocrine disrupters) mimic and disrupt functions adults are more resistant and recover easily, pregnant not so much. DES synthetic estrogen used to prevent spontaneous abortion
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