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Tens of thousands of synthetic chemicals have been synthesized and released into our environment for the past 50 years. These chemicals can interfere with hormone function. There is debate whether there are evidence of significant health risks to human population from exposure to these chemicals. Endocrine disruption is gaining public attention and many public policy decisions today involve chemicals known or suspected to interfere with hormone function. Endocrine disruption is not a new phenomenon: eg. 1930 test on animals demonstrated estrogenic properties of a number of industrial chemicals (eg. bisphenol a used in many plastics: eg. 1950s studied feminizing effect of ddt in roosters. Some pesticides and other industrial chemicals directly bind to or block hormone receptors, therefore initiating or blocking receptor-activated gene transcription (production of proteins) Other chemicals act indirectly by altering hormone production, hormone transport on binding proteins, receptor numbers on target organs, or hormone metabolism.

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