EESA10 ASSIGN 2.docx

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Department
Environmental Science
Course
EESA10H3
Professor
Silvija Stefanovic
Semester
Summer

Description
A1- What factors do yellow fever and malaria have in common? Yellow fever and malaria are both transmitted to humans by infected mosquitoes as viral or parasitic infections. The symptoms of both are similar as including headaches, weakness, chills, fever, muscle cramps, nausea, and back pain which generally begin to appear in a week and can lead to serious complications (WHO, 2009). Both are common in developing nations as some regions of Africa, and South America, typically tropical areas with high rainfall giving breeding places to mosquitoes. A2- What factors are different in comparing the two diseases? There are critical differences between yellow fever and malaria. Yellow fever is an acute viral haemorrhagic disease belonging to Flaviviridae family (Easmon, 2005). Malaria is caused by a parasite from the species of plasmodium. The incubation period of malaria is 7 to 30 days as compared to yellow fever which has incubation period ranging from 3 to 6 days (WHO, 2009). There is no vaccination for malaria as compared to yellow fever, which has an effective vaccination effective for a long period (Public Health Agency of Canada, 2008). Yellow fever infection can cause severe illness and death. Up to 50% of severely affected persons without treatment will die from yellow fever. As in severe cases, yellow fever can lead to bleeding, yellowing of the skin and eyes, organ failure and even death. Malaria can cause severe anemia, kidney failure, acute respiratory infection, coma and even death (Bupa, 2008). Finally, an individual infected with malaria does not get immune to malaria and can contact the infection again, as regarding to yellow fever which has not been found to infect an individual previously infected (New York Department of Health, 2006). B- Why are yellow fever and malaria not threats at present in North America? The eradication campaigns in 1940s and 1950s decreased the threat of malaria and yellow fever in North America (Lentnek, 2007). The widespread outbreaks of malaria motivated the U.S Public Health Service to fight against malaria using DDT as pesticide in malarial control worldwide (Centers For Disease Control And Prevention, 2004). The infected mosquitoes were removed and breeding places of mosquitoes were destroyed which led to decline in the cases of malaria and yellow fever. Moreover, in temperate zones which are characterized by strong seasonality and cold winter, malaria and yellow fever are effectively controlled (Sachs, 2002). C- Why is malaria such a significant hazard in Africa? Poverty-stricken communities such as Africa do not have the resources to protect their residents from malaria (EHS, 2005). In the United States, a long-lasting, insecticide-treated bed net would cost about $10; a full course of malaria medications, only $5. But many people in Africa are living on less than $2 a day and can't afford to buy these life-saving items (Global Ministries, 2009). Technical obstacles in malaria control in Africa such as insecticide resistance, vector behaviour, drug resistance in malarial parasites, financial problems in acknowledging the poor community is a really important determinant in malarial spread (Sharma, 2003). The civil wars in Africa cause migration of individuals to different areas as the ones heavily infected by malaria. The environmental degradation leads to malaria transmission more frequently. The high birth rates in Africa and no access to primary health care increases the risk of the population to be infected with malaria (Jacobs, 2009). D- Why does the number of West Nile virus cases in people increase in warmer weather? Mosquitoes are not evenly distributed. The global pattern of mosquito’s related infections is centered in the tropics. The temperate zones with strong seasonality and cold winter do not provide good breeding places for mosquitoes. The standing and stagnant water of about four days gives opportunities to mosquitoes to build nests and habitats. They usually do not breed near moving water such as currents, and do not necessarily require naturally found standing waters such as ponds. Rather, they are able to build nests out of birdbaths which have older water, pools, marshes, tires which collect water and even garbage cans which collect water (Sachs, 2002). As related to temperature, mosquitoes are usually active during a time period from June to September when humidity is high and temperature is warm (Apperson and Waldvogel, 2004). The high rainfall in summer increases the mosquito’s habitats and reproductive success. Since, the greater number of mosquitoes leads to the high probability of the population to get infected with West Nile Virus and the greater chance of the transmission of passing it on to the other individuals. All these reasons make individuals more susceptible to West Nile infections in warmer weather. 2A- Why are animals used in laboratory experiments in toxicology? Toxicology is the study of harmful effects to living organisms from substances which are foreign to them. The toxins may be naturally occurring in the environment or synthetic chemicals. Following the birth of the synthetic chemical industry in the late 1800s, the field of toxicology grew in response to the need to understand how tens of thousands of new substances might affect the health of workers and consumers involved in their production and use. The use of living animals to study the potential adverse effects of new drugs, food additives, pesticides, and other substances began in earnest during the 1920s.Today, most developed countries have enacted laws and regulations to control the marketing of drugs, vaccines, food additives, pesticides, industrial chemicals, and other substances of potential toxicological concern. Such regulations often prescribe a specific regime of toxicity testing to generate information that will enable government regulators to determine whether the benefits of a particular substance outweigh its risks to human health and/or the environment. Therefore, animals are used in regulatory risk assessment as hazard identification includes the determination of a substance's intrinsic toxicity (e.g., eye irritation, birth defects, or cancer) through the use of toxicity tests. The determination of the extent of human and/or environmental exposure to a substance, including the identification of specific populations exposed their composition and size, and the types, magnitudes, frequencies, and durations of exposure. A composite analysis of the hazard and exposure 2 assessment results to arrive at a "real world" estimate of health and/or ecological risk (General Toxicology, 2010). Animals such as rats, rabbits are used in laboratory testing as they have similarities to the human genome in acting against foreign substances. Animals have small gestation period, they mature quickly, and their offspring can be obtained in a small period of time, which enables researchers to study the effects of a particular substance on an individual as well as on the offspring minimizing the dangers related to the usage of the particular substance. 2B- Explain the dose-response curve. Dose-response curves can be used to plot the results of many kinds of experiments. The X-axis plots concentration of a drug or hormone. The Y-axis plots response, which could be almost anything. For example, the response might be enzyme activity, accumulation of an intracellular second messenger, membrane potential, secretion of a hormone, heart rate or contraction of a muscle. A dose-response defines the relationship based on a number of important assumptions. The first assumption is the response increases as the dosage is increased. The second assumption is that there is a threshold potential. A threshold potential is a dosage concentration below which there is no response. The lowest experimental dose which does not have a response of measureable effect is known as the No Observable Effect Level (NOEL). Another factor which is usually assumed is that once a maximum response is reached any further increases in the dose will not result in any increased effect (Extoxnet, 1993). Using the dose-response curve, several factors can be determined, including the EC50. The NOEL point can be recorded, as well as the maximum effect. EC50 is the drug concentration which invokes a response halfway between the maximum effect, and the baseline (NOEL) point. Also, the potency of a drug can also be measured. The potency of a drug or product is drug activity that is expressed in terms of the amount required to produce an effect of given intensity (University of Ottawa, 2009).The potency helps determine the strength of the drug, which alters
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