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The lack of a reliable treatment for smallpox hindered settlement of North America by the
English and French. (False)
The family name of the smallpox virus is poxviridae. (True)
The “Royal Experiment” began with Princess Caroline inoculating her children Amelia and
Caroline to promote the practice of variolation as a means to control smallpox infection.
The case mortality rate of variola major in naïve populations is low. (False)
The smallpox vaccine provided acquired immunity to smallpox. (True)
The Chinese performed variolation by taking material from a ripe pustule and rubbing it
into a scratch in one of the extremities of a non-immune person. (False)
Smallpox skin scabs are found on the healing pustules of smallpox sufferers and do not
spread infection. (False)
Two main advantages of the use of vaccination over variolation are that the recipient of the
vaccine is not infectious and the mortality rate is much lower in vaccination. (True)
In its most common form, transmission of the smallpox virus enters the body through
aspiration of contaminated fomites. (False)
Smallpox may have been the cause of the Plague of Antonine in the 2nd century AD. (True)
For smallpox, transmission by fomites is possible particularly if the strain is virulent.
Skin lesions caused by smallpox may lead to severe scarring or pock caused by the variola
major virus damaging the skin’s elasticity. (False)