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HLTC23H3 Study Guide - Final Guide: Apicomplexan Life Cycle


Department
Health Studies
Course Code
HLTC23H3
Professor
Jason Ramsay
Study Guide
Final

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Lecture #9: Golobal I The Four Horsemen of the Apocalypse and a Baby
Monday, March 14th/2011
Worlds #1 Most Dangerous Animal
Mosquito
Most Dangerous (Non-Human) Animals In Perspective
Venomous snakes: @250, 000 fatalities/year
Scorpions: @2000 fatalities/year
Big Cats: @800 fatalities/year
Crocodiles: @800 fatalities/year
Mosquitoes: @1-3 MILLION fatalities/year
Plasmodium Falciparum
Strain of malaria tha is particularly virulent
Appears to directly affect the central nervous system
Can cause neurological sequelae and epilepsy
Most common form of malaria
85% occurs in sub-Saharan Africa
Malaria In Context
350-500 million infections in humans
One to three million deaths annually
Malaria has killed more people than all wars and plagues combined
Transmitted by Anopheles mosquitoes
Vaccination efforts have failed
Famous author Wilbur Smith
I was born of a British stock on January 9, 1933 in Northern Rhodesia, now Zambia,
in Central Africa. As an infant of eighteen months I was struck down by cerebral
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malaria, delirious for ten days. The doctors told my parents that it was probably
better if I died, because if I survived I would be brain damaged. Despite the
primitive medical facilities available in Africa in those days, their prognosis proved
correct; I survived and am now only mildly crazy
Pathogenesis
The Protozoan parasites live inside cells, where they are largely hidden from the
immune response
Infection has a profound effect on the immune system and can cause immune
suppression
Dendritic cells suffer a maturation defect following interaction with infected
erythrocytes and become unable to induce protective liver-stage immunity
Scanning Electromicrograph
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