University of Toronto at Scarborough Department of Social Sciences HLTA01 Questions related to Lecture 6 Smallpox. Below are fifteen questions that you can use as a guide for a self-study of the topic on Smallpox. After you complete all assigned readings and look over the lecture slides, answer all questions below. 1. Describe the earliest historical evidence of smallpox. 2. Does evidence indicate endemicity of smallpox in earlier historical times? Discuss. 3. Smallpox has been implicated as having an impact on several historical wars. Discuss. 4. What is the agent responsible for smallpox? Are there several strains? What is the effect of this agent on humans? 5. How is smallpox transmitted?