Was smallpox seen as an yes, anyone and everyone was seen equal to
indiscriminate disease? get infected.
Is smallpox described in Yes , it is found mentioned in Indian and
ancient text? Chinese text as well as Egyptian where in fact
Pharaoh Ramses V died from smallpox.
In what century did the 16th century.
disease become serious in
What wars were connected -Possibly the Antonin Plague, when soldiers
with smallpox? returned home from war.
-16th century fall of the Aztec and Incas
empire where smallpox was brought by the
Spanish and Portuguese.
- Used a biological warfare by the French on
the Native Americans in the war (1754 - 1767).
What is the virus genus and Genus - Orthopoxivuris
family? family- Poxvirdae
What is another name for Variola Vera.
What are the two strains of Variola major- more virulent and about 30-
smallpox? 50% mortality, with vaccine only 3% mortality
Variola minor - Less virulent with only 2%
What other forms does Monkeypox, cowpox, camlepox, chickenpox,
Orthopoxvirus genus include?mousepox.
Explain what is Hemorrhagic Malignant and its a hemorrhagic form of
smallpox (blackpox). Variola major. Developed in approximately 5-
10% infected people. If case is severe it can
lead to extensive bleeding into the skin,
leaving black marks on the skin. Mortality rate
is 95%, even if patient is vaccinated, they may
How does this virus remain It must be continuously transmitted from
virulent? person to person but humans are only short
term carriers. This feature is the reason why
the disease was successfully removed.
What are some main forms of Through contact, inhalation of aerosols and by
transmission? contaminated fomites ( short period of time).
How does smallpox spread Multiplies in the mucous membranes of the
through out the body? mouth and nose then moves to the lymph nodes and then to internal organs via
How long can the variola About 2 days.
virus remain viable outside
the human host?
Describe the main clinical Acute onset- fever, malaise, rigors, vomiting,
manifestation. headache, backache and occasionally
delirium. 2-3 days after skin legions appear on
body. Can leave scaring.
Days 3,4,5, pimples come out. Days 6-10