PSYC62H3 Study Guide - Final Guide: Hypothalamus, Neuroanatomy, Vasopressin
Document Summary
Chapter 5; synaptic transmission, drugs, and chemical neuroanatomy. Classical transmitters: glutamate, gaba, ach, da, ne and 5-ht. Neurohormone-substances that are synthesized and released from neurons, but act as hormones (include hormones such as corticotrophin releasing factor; released from hypothalamic neurons and acts on the anterior pituitary. Neuromodulator-any substance that alter neurotransmission in some way; it does not show any direct shifts in membrane potential or conductance when tested for actions on its own. Dale s law/principle: a given neuron uses the same nt at all its synapses; thus a given neuron can be identified in terms of which transmitter it uses (dopaminergic, gabaergic etc. ) often a combination of classical + neuropeptide. It is not true that any given neuron can have any combination of transmitters. Monoamines (catecholamines): da, ne and e; as well as 5-ht (indolamine) Grouped together because the neurons that use them share biochemical features (ex. metabolic pathways, protein expression); some drugs act broadly on all monoamines.
