[BIO130H1] - Final Exam Guide - Everything you need to know! (82 pages long)

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29 Mar 2017
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UTSG
BIO130H1
FINAL EXAM
STUDY GUIDE
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Week 2: Membrane Transport of Small Molecules
Chapter 4, pages 147161
Outline
Permeability of lipid bilayer
Passive and active transport
Classes of Membrane Transport Proteins:
Uniporters
Symporters and antiporters
ATPases
Channel Proteins
Lipid bilayer is permeable to:
Hydrophobic molecules can pass
Small, uncharged polar molecules are generally not able to pass through(except for
water)
Not as fast as hydrophobic molecules
Movement via simple diffusion through the lipid bilayer
1) High concentration to low concentration
Down the concentration gradient
2) The more hydrophobic or nonpolar the molecule is,
Faster diffusion across the lipid bilayer
Lipid bilayer is impermeable to:
These require membrane proteins for transport
Dashed arrow denotes proteins
Membrane Transport Proteins
ALL Membrane transport proteins are multipass transmembrane proteins
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Multipass means they weave the membrane more than once
Note: does not mean they are all multiple alpha helices
proteinlined path across cell membrane
Transport polar and charged molecules
ions, sugars, amino acids, nucleotides, various cell metabolites
Different cell membranes
different transport proteins
Each transport protein is selective
transport specific class of molecules
Passive and Active transport
Concentration gradient (the arrow is not necessarily the direction of transport)
Simple diffusion
Passive transport
Goes down the concentration gradient
Does not require energy
Active transport
Moves against the concentration gradient
Requires energy
Channel protein do passive transport; Transporter protein can do both
Channel proteins do not interact a lot, do not bind strongly to the transported
molecule
Do not change conformation a lot
Transporter protein is the opposite
Some mediated active, and some passive transport
Transporter protein = Carrier proteins
Clicker Question
Concentration gradient and membrane potential
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