BIO230H1 Study Guide - Midterm Guide: Peroxisomal Targeting Signal, Microrna, Hydrolase

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5 Nov 2012
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BIO230H1 Full Course Notes
BIO230H1 Full Course Notes
Verified Note
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Document Summary

Co-activator and co-repressors does not directly bind to dna. Eukaryotic transcriptional activation: eukaryotic activator protein: modular design (bd & ad) Ways to alter chromatic structure: nucleosome sliding (atp-dependent, nucleosome removal (histone chaperones, histone exchange (histone chaperones, histone modifying enzyme, attract, position and modifying: Eukaryotic transcriptional repression: interfering with activator function (block bd, interfering with activator function (block ad, interaction with the general transcription factors, altering chromatin structure. Epigenetic inheritance: regulation of the transcriptome. Rna capping (additional of a modifies guanine nucleotide to 5 end) Rna splicing (removing introns of the rna by splicosome) Site of proper splicing bound by exon junction complex ( serve as a marker for properly splices rna) Different cells can splice an rna differently: alternative splicing: regulation of alternative splicing. Rna polymerase transfers protein complexes to rna: cstf (cleavage stimulation factor, cpsf (cleavage and polyadenylation specificity factor ) Poly-a polymerase(does not require template, not encode in the genome) add 200a nucleotide, bound by poly-a binding protein.