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BCH210H1 Study Guide - Acetyl-Coa, Glycogen, Pyruvic Acid

Course Code
Michael Baker

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BCH210H © Lisa Zhao 2012 | Page 1
Lecture 26: Metabolism and Bioenergetics
anabolismrxns that synthesize or make more complex molecules
building up of proteins from 20 AAs (thousands of diff proteins depending on seq)
makes things that are more complex
divergent20 AAs to thousands of proteins
NRG input required
ex. pyruvate (3C) to glucose, glucose to branched glycogen, pyruvate to acetyl coA, acetyl coA to
fatty acids
catabolismtakes something bigger and makes it smaller
ex. glycogen to glucose phosphate
ex. proteins to AA
ex. nucleic acids to nucleotides
ex. fats to FFA
convergentfrom thousands of proteins broken down to 20 AAs (smaller # of diff types)
NRG released
ex. glycolysisglucose to 2C and 3C parts through
ex. β-oxidationfatty acids to acetyl coA with release of NRG
ex. glycogenolysisbreakdown of glycogen to glucose-1-phosphate
provides NRG
catabolism and anabolism of many molecules during exercise/fasting and eating
conversion of one molecule to another ex. glucose (CHO) to fat
NRG released during catabolism can be used to drive anabolic pathways
catabolic paths fuel anabolic paths
usually requires many enzymes that work in sequence
complete change is a result of steps of changes with each step with an enzyme
product of one enzyme serves as substrate of next enzyme
linear pathway
there are problems
if there is a block in the pathway, you can’t get past it
ex. glycolysis
pathway can be made more efficient if there is an enzyme with multiple active sites built-in
or diff subunits
complex enzymeseparate enzymes held together covalently
enzyme cyclelast cycle regenerates the first substrate
imp components are the inputs and products put into and going out of the cycle
ex. Kreb’s Cycle
production of NRG and use of NRG
ATP is the principal carrier of NRG in cells
NRG is stored as ATP
ATP synthesis allows the conservation of NRG released in catabolism to be used in anabolic rxns
ATP is the intermediate shuttling bw catabolism and anabolism
ATPadenosine triphosphate
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