Lecture 33.docx

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University of Toronto St. George
Michael Baker

BCH210H © Lisa | Page 12 Lecture 33:  at 38 km  adrenaline is coursing through her blood  trying to get adrenaline up to mobilize more and more FFA that will take pressure off CHO  CHO is still being used  trying to avoid weakness in Krebs, hitting wall by gradually decreasing the use of glycogen at the later stage of the race  P/O ratio NADH = 2.5  7 x 2.5 = 17.5 ATP  P/O ratio FADH = 125  7 x 1.5 = 10.5 ATP  in total, 28 ATP from the 7 cycles of β-oxidation  acetyl CoA goes on to Krebs in mitochondrial matrix  P:O is P:0.5O 2 -  every time e pair goes through ETC, 0.5O is use2  whenever an ATP is made, an anhydride link is made from ADP to ATP, which generates a H O 2  1 ATP = 1 H O2 - -  thus, for every e pair coming down from e transport, a H O is mad2  1 FAD = 1 H O2  10.5 + 7 = 17.5 H O2  1 NAD = 1 H O 2  17.5 + 7 = 24.5 H O2  the one ATP formed by substrate-level phosphorylation in the auxillary rxn from Krebs does NOT give H 2  high temps increase body temp  dehydration  good that a lot of H O2is produced w β-oxidation of fat  as she is increasing fat percentage and lowering use of CHO, more and more H O is produc2d  fat reserves provide a lot of water generation i.e. camels, whales  β-oxidation produces a lot of ATP AND H O 2  the H O2rehydrates  the other problem is blood glucose  liver has limited amount of glycogen  athletes build up glycogen stores in muscle and liver  glycogen in liver is used to maintain blood sugar  glycogen levels are getting lower in muscle and liver  as she increases speed and relies on more and more fat, will she have enough glycogen to sustain muscles  there is another way to make glucose  liver needs to sustain blood sugar to keep organs working  liver is resourceful  liver uses things in the blood  fat mobilization produces glycerol (major water component from triglyceride hydrolysis)  glycerol has 3C, needs 2 to make glucose  liver uses gluconeogenesis to use the glycerol (a lot of glycerol from fat mobilization) BCH210H © Lisa| Page 212  can start from pyruvate lactate (recapture lactate that is produced)  but athletes don’t make a lot of lactate, so not a lot of pyruvate lactate made  pyruvate and lactate have 3C, so need 2 lactates  easier to make glucose from glycerol  glycerol kinase adds a P onto a –OH on glycerol to produce glycerol phosphate  a DH changes an –OH to a keto group, making dihydroxyacetone-P (DHA
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