BCH311H1 Study Guide - Winter 2018, Comprehensive Midterm Notes - Adenosine Triphosphate, Protein, Enzyme
12 Oct 2018
School
Course
Professor
BCH311H1
MIDTERM EXAM
STUDY GUIDE
Fall 2018
Jan. 5 2018
BCH311 – Lecture 1: Nucleic Acid Structure
Protein-nucleic acid complexes: Structure and function at the molecular level
• Structure is important for function of proteins AND nucleic acids
• DNA double helix is shown in the blue portion of the image
• Key Concept: (At a molecular level) Side chains are able to form non-covalent
interactions to recognize and pick up different gene products that ma be present
• 3', 5'-Phosphodiester Bridges Link Nucleotides Together
o Nucleotide: Phosphate + Sugar + Base
o RNA
find more resources at oneclass.com
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Jan. 5 2018
▪ Different nucleotides attached
▪ We can see that there is a Phosphate backbone linking 2 different
sugars - which gives the nucleic acids the ACID component
▪ Dissociated - which gives a negative charge
o DNA
▪ Also similar 3' to 5' phosphodiester linkages, but missing the
hydroxyl group
▪ Difference bases
o Creates bridges between sugars
o RECALL: always read from 5' to 3' direction wen listing or reading the
sequence
• The common DNA and RNA bases
o Purine
▪ 2 fused rings
▪ REMEMBER THE NUMBERING OF DIFFERENT ATOMS IN THE
STRUCTURE
▪ Always # so the itoges have the smallest number possible
▪ Counter clockwise for the above reason
o Adenine
▪ Added an amino group at C6
▪ Can also call it 6-amino-purine
o Guanine
▪ 2 different groups carbonyl at 6 (6-oxy) and amino group at
position 2 (2-amino)
▪ Since number 7 has the double bond it has priority
o Pyrimidine
▪ Single ring
find more resources at oneclass.com
find more resources at oneclass.com
