BIO120H1 Study Guide - Allele, Mutation

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BIO120H1 Full Course Notes

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In 1908 Hardy and Weinberg published papers showing that the binomial or multinomial could be applied in genetics to predict the frequencies of genotypes when allele frequencies where known. The formal algebraic proof of this Hardy-Weinberg Equilibrium Law assumes that there is no mutation in the population. This assumption is necessary, because a. organisms reproduce sexually and litter or family sizes vary. b. populations will exhibit random sampling changes in allele frequency. c. populations are not infinite and the Hardy-Weinberg proof is only a very crude approximation when natural selection is acting. d. populations are not closed and reproduce both sexually and asexually so an infinite size population is required to preserve genetic variation. e. allowing alleles to change would alter their frequencies.

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Q1. What are alleles?Different forms of the same gene.Different genes.The different characteristics of an organism.Genes found only in humans.Q2. If you add up the frequency of homozygotes + the frequency of heterozygotes for one gene (i.e. at one locus) in a population, what number do you get?Q3. People who are heterozygous for the sickle-cell allele:Are susceptible to malaria but not sickle-cell anemia.Are susceptible to sickle-cell anemia but not malaria.Are not susceptible to either sickle-cell anemia or malaria.Are susceptible to both sickle-cecell anemia and malaria.Q4. In the case study in this lab, which genotype is represented by "2pq" in the Hardy-Weinberg equation?Homozygous HbAHomozygous HbSHeterozygous HbA/HbSNo specific genotypeQ5. Suppose that, in an isolated village, the proportion of individuals that have sickle-cell anemia is 0.1 (or 1 of every 10 people). What proportion of the population should be sickle-cell carriers, according to Hardy-Weinberg expectations?Q6. When you simulated the elimination of malaria at the beginning of the lab, once the allele frequencies stabilized, what was the frequency of the HbA allele?Q7. When you investigated regional differences, what was the frequency (over many generations) of the HbS allele in the village in the "slightly wet" part of Africa?Q8. What is the number of deaths due to sickle-cell anemia in a region without mosquitoes expected to be?Very lowVery highModerateRelated to the frequency of malaria allelesQ9. As long as there are multiple alleles of a gene in a population, why will the frequencies of the alleles always change over time?Because natural selection changes all allele frequencies in populations over time.Because genetic drift causes random fluctuations of allele frequencies in populations.Because diseases will eliminate some of the alleles, generating fluctuations in their frequencies.Because allele frequencies fluctuate before the alleles eventually become fixed.Q10. Imagine a huge population with a gene that has ten functionally equivalent, neutral alleles. A small but genetically representative group of individuals from the big population is transported to an island, forming a small population. Which of the statements below best describes what will likely happen over time, and why?Because natural selection doesn't act on neutral alleles, the frequencies in the two populations should remain the same over time.Genetic drift will cause one allele to first become fixed in the island population, and later to become fixed in the original, large population.Genetic drift will result in the allele frequencies of the two populations diverging over time, with alleles being lost sooner in the island population.The allele frequencies of the two populations will change similarly due to a combination of genetic drift natural selection.

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Evolution is change over ____________. Why is evolution an important concept in biology?

What is a population? How can you identify a population in nature?

What is the ultimate source of random variation in a population? Is this the only source of variation, why or why not?

What is a gene pool? Why is it important to our study of evolution?

How is variation inherited in a population? HINT: There are at least two main contributors to this variation. You should be focusing on gametes!

What is microevolution versus macroevolution?

How do the peppered moths show us microevolution in nature? Why is this NOT macroevolution? HINT: you should consider alleles and mating in your answer.

Do you believe that the Hardy-Weinberg equilibrium is common in nature? Why or why not? In your answer, you should incorporate your knowledge of populations, evolution, and genetics.

Evolution is driven by adaptation and natural selection. In populations, we refer to organisms that are âmost fit.â Explain how evolution and the environment would result in organisms that are âmost fit.â In your answer, indicate whether the âmost fitâ organism today is likely to be the âmost fitâ organism in the future and why.

Microevolution is a change in the frequency of ___________________ in a population but has not resulted in a speciation event thus far. Given this, what factors could lead to a speciation event for this population?

How would you know that a population had divided into two different species (macroevolution)? How could you test for a speciation event experimentally?

BIO120H1 Study Guide - Allele, Mutation

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