BIO130H1 Study Guide - Peripheral Membrane Protein, Electrochemical Gradient, Atp Synthase
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BIO130H1 Full Course Notes
Verified Note
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Document Summary
Ends on cell surface (exoface: fatty acid. Anchor added by cytosolic enzymes, directs it to cytosolic face. Peripheral membrane protein attached to a integral protein. Bound to either face by non covalent interactions. Using energy of 1 molc going down gradient to bring other up gradient. Both examples use na+ gradient to move against gradient. Eventually it will be exhausted therefore: na+/k+ pump to restore the gradient. Cooperative binding leads to conformational changes (state a state b) Using free energy stored in na gradient to moves h+ out of cell or into lysosome. Maintain optimal ph levels in cytosol and acidic in lysosome. Moves against gradients: f-type and v-type atpase (proton pump) Use h+ gradient to drive synthesis of atp. Both moved against gradient to create na+ gradient used to transport glucose into cell, maintain ph &v: 2k release. Uses atp to pump h+ into lysosomes and vacuoles. Each uses 2 atp eg. multidrug resistence protein.
