BIO130 Section Two Guide (4)

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University of Toronto St. George
Kenneth Yip

Chapter 16 The Cytoskeleton Molecular Motors - Motor proteins bind to polarized cytoskeletal filaments and use the energy derived from ATP hydrolysis to move (differ in cargo, direction of travel, type of filament they bind to) o Many carry membrane-enclosed organelles (mitochondria, Golgi stacks, vesicles) o Generate motion by coupling ATP hydrolysis to a large-scale conformational change in a protein - The motor proteins associate with their filament tracks through a head region or motor domain that binds and hydrolyzes ATP o Through a mechano-chemical cycle of filament binding, conformation change, filament release, conformational relaxation, and filament rebinding, the motor protein and its associated cargo move one step at a time along the filament The motor domain determines the identity of the track and the direction of movement, the tail determines the identity of the cargo therefore, the biological function of that motor protein Actin-Based Motor Proteins are Members of the Myosin Superfamily - Skeletal muscle myosin generates the force for muscle contraction myosin II is an elongated protein that is formed form two heavy chains and two copies of each of two light chains o Each heavy chain has a globu
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