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Midterm 1 Review Notes

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David Lovejoy

BIO270 Midterm 1 Test Lecture 1 10 Body Systems & Their Functions - Integumentary (skin): covers. - Musculoskeletal: support & movement. 4 exchange b/w the internal & external - Respiratory: exchange gases. - Digestion: nutrients & water, waste. - Urinary: removes excess waste & water. - Reproductive: produces eggs & sperm. 4 extend throughout the body - Circulatory: distributes materials. - Nervous: coordinate body functions - Endocrine: coordinate body functions. - Immune: protect interior. What is Physiology? - The knowledge of nature Aristotle - The healing power of nature Hippocrates - Definition: The study of the normal functioning of a living organism & its component parts, including all its chemical & physical processes. - The study of how animals work Knut Schmidt-Nielsen - Structure & function of various parts how these parts work together. o One of the basic premises of physiology in any science is that function follows structure, what the function is going to be depends on what the structures are like. - Diversity of animals more than 1 million species live on Earth. o One of the things in physiology that we look at is that over 1 million species that live on earth, what are the commonalities & what is unique about them & what does that mean about their functioning & how theyve adapted to the environment that theyre in so what does that mean about our bodies & how our functions work? - Unifying themes apply to all physiological processes. Physiological Sub-Disciplines - Based on: o Biological level of organization: Atoms Molecules Cells Tissues Organs Organ Systems Organisms Populations Communities Ecosystems Biosphere Cell & molecular physiology: genetics, metabolism, organelles the physiology that they work with is more on the cellular level, how the functioning of all cells & the molecules will affect the function of the organism. Systems physiology: function of organs Organismal physiology: whole animal Ecological physiology: animal & its environment Integrative physiology: multiple levels of organization Physiologists often study processes at more than one level: Reductionism: understand a system by studying the function of its parts. Emergence: the whole is more than the sum of its parts. o Process that cause physiological variation Developmental physiology: Change as the animal grows. Environmental physiology: Change in response to environment. Evolutionary physiology: Change due to natural selection. o Ultimate goals of the research Pure physiology: No specific goal, other than knowledge. Applied physiology: Medical physiology Comparative physiology August Krogh principle: For every biological system there is an organism on which it can be most conveniently studied. o Many physiological questions encompass elements from each sub-discipline History of Animal Physiology: Ancient Times - Hippocrates: Father of medicine; Careful observation. - Aristotle: Father of natural history; Relationship b/w structure & function. st - Claudius Galenus, Galen: 1 experimental physiology; Founder of physiology. o He was taking care of a lot gladiators & while he was doing that, he was learning about the human body, how the blood worked & how to stop blood flow & severed limbs & also he was doing some animal studies & try to figure out the similarities b/w them, how to work with the animals in order to better serve the humans he did a lot of experimental work to try out things on animals to see how they would affect them. History of Animal Physiology: Middle Times - Ibn al-Nafis: Anatomy of heart & lungs. o It was not until we go to the Muslim community where they started to question things in the middle th of the 13 century. - Jean-Francois Fernal: Outlined current knowledge of human health & disease. o He was one of the 1 ones to really look at a combination of physio & health. - Andreas Vesalius: 1 modern anatomy textbook. - William Harvey: Circulation of blood through the body by contractions of the heart. Chemical or Physical? The Answer - Herman Boerhaave & Albrecht von Haller: Bodily functions are a combination of chemical & physical processes. o Prior to this all physiologists were either: Iatrochemists (body functions involved only chemical reactions) or Iatrophysicists (body functions involved only physical processes). - Matthias Schleiden & Theodar Schwann: Cell theory organisms are made up of units called cells. - Claude Bernard: Milieu interieur (internal environment) internal environment distinct from external environment. - Walter Cannon Homeostasis: the body needs to regulate itself to maintain a proper environment to function. - Per Scholander: Comparative physiology to start looking at different animals/organisms & comparing them to see what they have in common & seeing what they have that are distinct. - C. Ladd Prosser: Central pattern generators the idea that you have specific cells in your brain or in different areas of the body that are the processors that make something happen. - Knut Schmidt Nielsen: Animals in harsh & unusual environments to test their limits of what their processes are & then to try to relate that back to humans. - George Bartholomew: Ecological physiology. - Peter Hochachka & George Somero: Biochemical adaptations. Unifying Themes in Physiology 1. Physiological processes obey physical & chemical laws. 2. Physiological processes are usually regulated: Homeostasis maintenance of internal constancy. 3. Physiological phenotype is the product of genotype & environment - Genotype: genetic makeup. - Phenotype: morphology, physiology & behaviour. - The phenotype is dependent on your genes interacting with the environment not only outside your body but also within your body. This is why every cell in your body isnt identical although every cell in your body has the same DNA, aside from the reproductive cells due to epigenetics, its how the environment reacts with genes & vice versa the genotype & the environment will then be displayed as your morphology, physiology & behaviour. 4. Genotype is the product of evolution. Physics & Chemistry - Physical properties of cells & tissues are linked to structure & function. - Molecular interactions are governed by chemical reactions Thermodynamics & kinetics. - Electrical laws describe membrane function, especially excitable cells Nerves & muscles. o Excitable cells: every cell in the body has an electrical potential, a difference in electrical potential in the charge within the cell compared to the outside of the cell, theres an electrical field around every cell but excitable cells can change & adapt depending on what those signals are. - Body size influences physiological processes: Allometric scaling. o Originally, people thought body mass was directly related to the metabolic rate in the organism, that the bigger the organism, the higher the metabolic rate was. So if this is true, if there was a direct relationship b/w the 2, it should follow the line of unity, however it doesnt. There isnt a direct relationship b/w the body surface compared to the metabolic rate & they did that through experimentation. Physiological Regulation - Strategies for coping with changing conditions: o Conformers: allow internal conditions to change with external conditions not humans, but other animals such as snake & fish. o Regulators: maintain relatively constant internal conditions regardless of external conditions humans. - Homeostasis: o Maintenance of internal conditions in the face of environmental perturbations. o Controlled by feedback loops or reflex control pathways: Negative feedback loops: the idea is that when the conditions change in one direction, there is a counter-change to bring it back to the set point. Positive feedback loops: things that tend to perpetuate & it make it stronger & stronger reactions. Phenotype, Genotype & the Environment - Phenotype is the product of genotype & its interaction with the environment. o Genotype: genetic makeup. o Phenotype: morphology, physiology & behaviour. o Phenotype plasticity: single genotype generates more than one phenotype depending on environmental conditions. - Factors Influencing Phenotype: The adult phenotype is dependent on the genotype, which is dependent on th
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