CSB327H1 Study Guide - Midterm Guide: Signal Recognition Particle, Signal Peptide, Basal Lamina

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Two major types of ecms rest: basal lamina (bl) or basement membranes: thin, sheet-like ecm upon which epithelial cells, surround muscle and adipose cells, peripheral nerves, connective tissue ecm: most abundant, e. g. Migration, secretion, communication, apoptosis, pattern formation, tissue remodeling, Secretory pathway of ecm molecules: nucleus transcription -> mrna, peptide/protein translation begins in the cytosol, signal peptide exposed (no longer masked by ribosome) when ~70 aa have been polymerized, signal peptide. P54 (signal-sequence-binding-domain: crystal structure contains large, exposed binding pocket lined with large number of hydrophobic methionine residues, met residues (forming a flexible, unbranched chain) bind to hydrophobic domain of signal peptides. Csb327h1 tt1 notes made by man lai ho: hydrophobic signal peptide diffuse into bilayer, rapidly degraded by signal peptide peptidases, protein from er -> golgi apparatus -> secretory vesicles -> cell surface -> ecm. Fibroblast cells: cells of connective tissue that produce and secrete ecm molecules: occurs in various shapes (e. g. fusiform/spindle-shaped, stellate/star-like, morphologically heterogeneous.

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