CSB328H1 Study Guide - Midterm Guide: Myogenin, Pax7, Myf5

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aquamarinesardine609

6 Mar 2017

School

UTSG

Department

Cell and Systems Biology

Course

CSB328H1

Professor

Godt Dorothea

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Document Summary

Lecture 12 - october 24th - transcription factors and enhancers. P52-66 anatomy of the gene (full chapter important) P568-569 determination of myotome - mrfs: transcription factors cause the specification of the somitic primordia. Enhancers are cis-regulatory elements of a gene (ex. bhlh transcription factor dimer) Enhancer elements can be located upstream, downstream of a transcription unit or located in introns within the transcription unit: who binds to the enhancer, what gene does the enhancer regulate. Same sequence of events in limb for mrna to be expressed in the limbs, and brain specific enhancer is not used: distribution and complexity of cis-regulatory sequence. Enhancer a regulate gene a and c transcription unit: enhancer b regulate gene b tu, the brain region might have repression from other parts of the body. Enhancer c regulate gene a and c tu: master regulators of muscle development, myogenic regulatory factors (mrfs) = myogenic proteins from dorsal and ventral myotome.

Related Questions

1 DNA sequences found in introns provide [A] amino acid sequence information.

[B] regulatory information.
[C] no known useful information.

[D] structure for the gene.
[E] alternative DNA splicing possibilities.

3. The TATA box is a(n)
[A] sequence close to the promoter region of many genes.
[B] square-shaped sequence.
[C] enhancer consensus sequence.
[D] activator sequence necessary for proper translation.
[E] None of the above

5. Regarding genes and gene expression, which of the following is not a difference between prokaryotes and eukaryotes
[A] Eukaryotic DNA does not contain a TATA box close to the initiation site as does prokaryotic DNA.

[B] In eukaryotes, RNA polymerase requires

'transcription factors'or initiation.

[C] Prokaryotic genes are often grouped together in

operons.

[D] In eukaryotes, the regulation of several genes at once requires common control elements in each of the genes.
[E] There is a diversity of eukaryotic polymerases that is reflected in the diversity of eukaryotic promoters.

10) In eukaryotic cells, a repressor

[A] is made of DNA.
[B] binds to the enhancer region to block transcription. [

C] is located both upstream and downstream from the promoter.
[D] binds to the operator to block RNA polymerase.

[E] binds to a silencer to reduce transcription rates.

Coordinated regulation of genes in eukaryotic cells [A] is the result of positioning the same regulatory sequence in front of each gene.
[B] results from all of those genes being under the control of one promoter.

[C] occurs because related genes all have the same

operons.
[D] occurs because enhancers cause DNA to bend.

CSB328H1 Study Guide - Midterm Guide: Myogenin, Pax7, Myf5

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