CSB328H1 Study Guide - Activin And Inhibin, Egg, Morphogen
25 Jan 2014
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Csb328h1 lisa zhao 2013 | page 1. From blastomere to specific cell type, the cell must first be committed to a certain fate, & then differentiate. 2 stages of the commitment process: specification the fate of a cell/tissue is specified when it is capable of differentiating autonomously in a neutral envmt. Cell commitment is still reversible: determination a cell/tissue is determined when it is capable of differentiating autonomously even when placed in another region of the embryo (non-neutral envmt) 3 strategies of specification: (diff combinations are used in diff species: autonomous, conditional, syncytial. Autonomous specification: diff regions of the egg cytoplasm contain diff morphogenetic determinants (transcription factors) that direct cell dvpmt (fig p2. 1) w/o signals from other cells. Ex. differentiation of trochoblast cells in the snail. Trochoblast cells become ciliated (fig p2. 1c), even when isolated from other cells (fig 2. 1d-g) Ex. each blastomere from the tunicate embryo forms its respective cell type even when separated (fig p2. 2)
