CSB328H1 Study Guide - Final Guide: Histone Methyltransferase, Histone Deacetylase, Paraxial Mesoderm
7 Sep 2012
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Nuclear equivalence every cell is genetically equivalent. Weismann: nuclear determinants are progressively lost as somatic cells divide. Cells are different because determinants in the nuclei were asymmetrically divided: determinants dictate what cells differentiate into, implies the nuclei of differentiated cells are not equivalent. Every cell in the body has the same number of chromosomes. Driesch: demonstrates the concept of regulative development. Cells communicate with each other to generate one single larva: each nucleus has all the determinants to drive complete development, implies the nuclei are equivalent. Spemann: blastula stage nucleus is able to drive complete development, suggests nuclear determinants are not lost as cells divide, implies the blastula stage nuclei are equivalent. Somatic nuclear transfer: demonstrates that the nuclei of fully differentiated cells still retain all the necessary information to drive complete development, implies fully differentiated cells are equivalent. Poke unfertilized host egg with glass needle. Mitotic spindles and chromosomes will spill out.
