CSB332H1 Study Guide - Quiz Guide: Tetraodontidae, Tetrodotoxin, Invertebrate

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The protein spans the membrane, with a central water-filled pore open to both the intracellular and extracellular spaces. On each side of the membrane, the pore widens to form a vestibule. Within the plane of the membrane, a segment of the pore is constricted and lined with a ring of negative charges to form a selectivity filter for cations and vice versa for anions. The channel contains a gate that opens and closes to control ion movement through the channel. The size varies considerably from 1 channel type to the next and some have additional structural features. Some are permeable to cations, some to anions. Some are selective for a single ion species. Others are relatively nonspecific, allowing the passage of even small organic cations. Anions channels involved in signaling tend to have low specificity but are referred to as cl- channels, because cl- is the major permeant anion in biological solutions.

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